Hydroxygenkwanin – (20243-59-8)

Genkwanin is an O-methylated flavone, a type of flavonoid found in the seeds of Alnus glutinosa, the leaves of ferns Notholaena bryopoda and Asplenium normale, and the leaves of trees in the genus Aquilaria. It has been studied for its potential pharmacological properties, including antioxidant, anti-glioma, and anticancer effects.

Hydroxygenkwanin, a derivative of genkwanin, has shown promise in enhancing the sensitivity of cancer cells to chemotherapy by inhibiting DNA damage response and reversing multidrug resistance mediated by ABCG2 transporters. Research indicates that hydroxygenkwanin can inhibit homologous recombination, suppress RAD51 expression, and enhance the efficacy of cytotoxic drugs in multidrug-resistant cancer cells. These findings suggest its potential as a chemotherapy adjuvant in cancer treatment.

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Sources:

https://en.wikipedia.org/wiki/Genkwanin
https://www.medchemexpress.com/hydroxygenkwanin.html
https://www.medkoo.com/products/50857
https://pubmed.ncbi.nlm.nih.gov/34575923/
https://pubmed.ncbi.nlm.nih.gov/36361555/